If you're looking for a way to take the edge off your liberal guilt this holiday season, look no further than Child's Play, a charity organized by the Penny Arcade guys to benefit sick children in five countries-- and, as a bonus, combat the public perception that gamers (and video games) are good for nothing.
In their own words: "We collect no administrative fees [my link -ed.] or other charges, 100% of all gifts and donations go directly to our partner hospitals, to help make life a little brighter for a sick child... When gamers give back, it makes a difference!"
Can't handle the pressure of actually selecting which games or toys to donate? You can also make a monetary contribution via PayPal.